Hearing loss is a common problem that affects millions of people around the world. The factors that cause this include age, noise exposure and genetics. In fact, approximately 50% of hearing loss cases are caused by genetic factors. The genetic mutation that causes genetic hearing loss is progressive and worsens over time. It is a type of hearing loss that can be particularly difficult to treat, as it is often resistant to traditional approaches such as hearing aids or cochlear implants.

Rescue Hearing is a dedicated life sciences company with innovative solutions to end hearing loss. One of the main approaches we are exploring is the use of gene therapy to target the TMPRSS3 gene.

The TMPRSS3 Gene

The TMPRSS3 gene is responsible for encoding a protein called transmembrane protease, serine 3 (TMPRSS3), which is essential for the proper functioning of the hair cells in the inner ear. The brain interprets the electrical signals. When there is a mutation in the TMPRSS3 gene, it can lead to hearing loss. In some cases, a mutation in the TMPRSS3 gene can lead to progressive or genetic hearing loss.

Gene Therapy

Gene therapy involves introducing a healthy copy of a gene into the cells of individuals with a mutation in the gene. This can be done through the use of viral vectors, which are viruses that have been modified to carry the healthy gene.  The goal of gene therapy is to replace the mutated copy of the gene with the healthy copy, allowing the cells to function normally.

Chart of the different types of hearing loss. This chart specifies what percentage of each type affects people including genetic hearing loss

Gene therapy has the potential to be a powerful tool, as it can address the root cause of the problem. This is in contrast to traditional treatments such as hearing aids or cochlear implants, which only address the symptoms.

Gene therapy is still relatively new and we will have to overcome more challenges to become a viable treatment option. Developing a viral vector that is able to effectively deliver the healthy copy of the TMPRSS3 gene is one challenge. Another challenge: ensuring the healthy copy of the gene is able to function properly once it is inside the cells.


Rescue Hearing Inc.

Despite these challenges, Rescue Hearing Inc is making significant progress in the development of a gene therapy treatment for progressive or genetic hearing loss. The company is working closely with researchers and scientists to advance the treatment and bring it to clinical trials. We are also collaborating with other organizations to find additional solutions to benefit the lives of individuals

Rescue Hearing Inc is is actively working to end progressive or genetic hearing loss through the use of gene therapy. By targeting the TMPRSS3 gene we will develop the treatment to target the root cause. The work we are doing at Rescue Hearing Inc holds great promise for the future treatment of hearing loss.